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Monitor Intently (1)pentobarbital will minimize the extent or impact of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a minimize in fentanyl plasma concentrations, deficiency of efficacy or, potentially, enhancement of